This information is from "DuQuoin, Gateway to Egypt" written in 1955.  It is a report of a History Committee and DuQuoin Community Study and Development.
I have found only 1 Du Quoin city directory.  It is for 1934.

          WHAT IS                                                        WHAT WAS

Valu Shop   John Humphrey Grocery
Daniels Store   Post Office and small store Hamer Humphrey
West Part Daniels   H. Melton later Holloways
Confectionery, also Prentice
Andersons
Lucille Strattons   Porter Barber Shop
Angel Drug Corner   A. C. Brookings Drug
Walker Haberdashery   Pope Dry Goods
R. Eison Shoe Store   Pope Shoe Store
Wymans Stores   Company store - miners Store
Loucks   Kneblekamp Saloon earlier restaurant
Wootons   Saloon
Woolworths   Ma & Pa Ausburgs Restaurant & Barber Shop
Midwest (West Side)   Mark Davic Livery Stable & later a saloon
    with restaurant in back
Next to Maclin Drug   Louis Croessmann and sons
Maclin Drug   W. W. Parks Drug
Guy Alongi Tavern   1st, J. Fritz butcher shop, 2nd, clothing store
    3rd, Saloon
Keiners   ?
Duncan Furniture   Schlepers Store
Music Store   Schleper Grocery
Across from Catholic Church   Pflanz Saloon west, Jake Druar Livery Stable
Chevrolet   Geo. Pugh Tombstone Building
Southern Barbecue   Knight Saloon
Bianco Drug   Horn Bank
Morris Supply   Horn's Mill
Corner Main & Oak   Howell Maclin Saloon
Croessmann Wholesale   Wiley Bates Harness Shop
Chief Restaurant
(Kelly & Popham)
  Saloon and Restaurant
Rosies Cafe   Saloon
Next door east of Rosies   Model Clothing Store
Hindman Hardware   P. D. Mifflin Mercantile Co.
M. Werners   Restaurant (Owned & run by several thru the years)
West End of Bank   G. S. Smith Store
Du Quoin State Bank   Exchange Bank
A.& P. Store   Ward Livery Stable, later, Edgar Davis Laundry
Dr. Duffs Office   Laundry
Sims Cleaning Shop   New Merchants Hotel
Sportmans Center   J. M. Browning Mercantile
Dennie Jewelry   John Frizzell Clother, later, Frank Dry
Jones Drug   Neighbors Furniture, Opera House upstairs
W. B. Guthrie   White Drug, later, Knauer Drug
Howard Henderson   R. E. Brown Clothier
F. Poiter Barber Shop   Chris Bergman Dry Goods
Louis Gremmels   Kimmel Hardware
Rechters   Van Keuren and Eddleman Grocery
Sanitary Market   far back, A. N. Kingsbury, then C. E. Kelly Mkt.
Brocks Walgreen   Davis Store, later, M. Mifflin Paper and Paint
Friedmans   Wm. Croessman Grocery
Friedmans   Mrs. Johnson Millinery
B. and B.   Repair Shop
D. X. Station   Frank Wells Grocery
Post Office   Home owned by David Haywood
Worthingtons   Bakery Shop owned by J. Hemingway, later
Andrew Mayor
Schenks Garage   J. C. Eade Planing Mill, later Majestic Opera House
Township High School   A. J. Blakeslee Foundry
Huies Auto   B. F. Echols Home & Sewing Machine Shop
James Sawyer Barber Shop   George Croessmann Meat Market
Fox Restaurant   W. E. Brookings Mercantile, Forester Mine Store
Lot next to Corner   S. T. Ring Photograph Shop
Kennedy Studio   Mrs. W. T. Hooey Millinery
Daileys   Ed. Pierce Sewing Machine
Wholesale House   Dr. W. T. Maclins office, Opp's Photo Studio

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